The current paper describes three models of research-practice collaboration to scale up evidence-based practices: (1) the Rolling Cohort model in England, (2) the Cascading Dissemination model, and (3) the Community Development Team model. Treatment Foster Care of Oregon (TFCO) and KEEP are the focal evidence-based practices, both designed to improve outcomes for children and families in the child welfare, juvenile justice, and mental health systems. The three scale-up models each originated from collaboration between community partners and researchers with the goal of wide-spread implementation and sustainability of TFCO/KEEP. All three of the models have been or are currently being tested in the context of randomized controlled trials. An overview of the development of each model, the policy frameworks in which they are embedded, system challenges encountered during scale-up, and lessons learned are presented. Common elements of successful scale-up efforts, barriers, factors relating to enduring practice relationships, and future research directions are discussed.