Heterogeneity in the longitudinal course of depressive symptoms was studied using general growth mixture modeling for young men in the Oregon Youth Study (N = 206) from ages 15 to 24 years. Four trajectory classes were identified: the very low, the moderate decreasing, the high decreasing, and the high persistent classes. The three lowest classes differed primarily quantitatively with the initial level or mean level across time being the major determinant of class differences, whereas the high persistent class appeared qualitatively different in terms of long-term developmental trends and variation. Findings from univariate and multivariate analyses revealed specific effects of childhood parental, contextual, and individual risk factors on the class membership as well as on the growth within each trajectory class.