We evaluated an integrated family-based outpatient treatment for adolescents (OPT-A) to be delivered in a community mental health center by a single therapist to assess treatments for comorbidities commonly seen in adolescents who present to community mental health centers, including internalizing, externalizing, and substance used problems. OPT-A had effects on abstinence rates, retention, motivation, parent involvement, and satisfaction, but not on internalizing or externalizing problems.