This article summarizes 30 years of research at the Oregon Social Learning Center (OSLC) investigating the sources, mechanisms, sequelae, treatment, and prevention of child and adolescent antisocial behavior. The social interaction learning model guiding the research and applied programs is delineated. The model spotlights the key role parents play in their children’s socialization. A broad review of the OSLC literature is presented with key references. The discussion of OSLC parent management training (PMT) efficacy trials covers positive outcomes for parents and children, the temporal generality of those outcomes, and the replication of beneficial effects using sophisticated assessment methods. The article articulates the main elements of PMT and applies them to a hypothetical case example. Further directions for dissemination are discussed.