The present study investigated the role of parental use of alcohol, cigarettes, and marijuana on lagged changes in specific substance use of their adolescent offspring over a 6-year period. Demonstrates the use of a general model for latent variable growth analysis which takes into account cluster sampling. Multilevel Latent Growth Modeling was used to analyze longitudinal and multilevel data for adolescent and parent substance use measured at 4 annual time points. An associative latent growth model was tested for alcohol, marijuana, and cigarette use. Ss were 435 target adolescents (aged 11-15 yrs old), 203 siblings, and 566 parents. Hypotheses concerning the shape of the growth curve and the extent of individual differences in the common trajectory over time were tested. The effects of marital and family status and SES on family levels of substance use were also examined. Ss completed a series of self-report questionnaires designed to assess substance use and selected psychosocial characteristics. Initial levels of use were strongly interrelated, indicating that, in general, use of one substance at a higher level is likely to be reflective of use of other substances at elevated levels. Program specifications and input data for the latent variable modeling are appended.