fMRI Study of Inhibitory Control

Based on Research Conducted at OSLC

fMRI Study of Inhibitory Control is designed to examine children’s behavioral performance and brain activation during an inhibitory control task.

Project Overview

MRIT: An fMRI Study of Inhibitory Control is designed to examine children’s behavioral performance and brain activation during an inhibitory control task. The study involves data collection with a subsample of 9–13 year-old children who participated in a randomized efficacy trial of Treatment Foster Care of Oregon for Preschoolers (TFCO-P). The randomized efficacy trial of TFCO-P started with three groups of preschool-aged children: foster children who received the TFCO-P intervention, foster children who did not received the TFCO-P intervention, and children who were not in foster care. The current study investigates the long-term impact of early experiences and the TFCO-P intervention on the structure of specific brain regions assessed via magnetic resonance imaging (MRI), connections between specific brain regions assessed via diffusion tensor imaging (DTI), and activation of specific brain regions during an inhibitory control task via functional magnetic resonance imaging (fMRI).

Year Project Completed: 2011
Funder: National Institute on Drug Abuse

Principal Investigator

Jacqueline Bruce, Ph.D.

Research Scientist
Oregon Social Learning Center

Active Research Projects

Primary Research and Clinical Interests

Dr. Bruce received her Ph.D. in Child Clinical Psychology from the University of Minnesota and has been a Research Scientist at the Oregon Social Learning Center since 2009. Her program of research focuses on the impact of early adverse experiences (e.g., child maltreatment and multiple caregiver disruptions) on the development of young children. She is particularly interested in the development of behavioral regulation (the ability to voluntarily regulate one’s behavior to meet the demands of the situation) and the underlying neural systems. For example, she has collected event-related potential (ERP) and event-related functional magnetic resonance imaging (fMRI) data with maltreated foster children and nonmaltreated children during different inhibitory control tasks. Currently, Dr Bruce is the principal investigator on a study designed to investigate the effects of early adverse experiences and the cognitive processes underlying behavioral regulation on alcohol use in maltreated adolescents and a study designed to examine the behavioral and electrophysiological performance of children and adolescents on a decision-making task. She is also a co-investigator on a randomized efficacy trial of a school readiness intervention program with foster children and a multisite Center investigating the behavioral and neurobiological impacts of early adverse experiences in humans and nonhuman primates.